The total syntheses of basiliolide C, epi-basiliolide C, and protecting-group-free total syntheses of transtaganolides C and D.

A general approach to the basiliolide/transtaganolide natural products: total syntheses of basiliolide B, epi-8-basiliolide B, transtaganolide C, and transtaganolide D.

Protecting group free enantiospecific total syntheses of structurally diverse natural products of the tetrahydrocannabinoid family.

A simple, highly diastereoselective, Lewis acid catalyzed Friedel-Crafts coupling of a cyclic allylic alcohol with resorcinol derivatives has been developed. The method was applied for the enantiospecific total syntheses of structurally diverse natural products such as machaeriol-D, Δ(8)-THC, Δ(9)-THC, epi-perrottetinene and their analogues. Synthesis of both natural products and their enantiom...

A biomimetic synthesis of (±)-basiliolide B.

A highly diastereoselective and practical biomimetic total synthesis of (±)-basiliolide B has been achieved through the study of the two proposed biosynthetic pathways (O-methylation and O-acylation) for the unprecedented 7-methoxy-4,5-dihydro-3H-oxepin-2-one (C ring). The synthesis featured a cyclopropanation/ring opening strategy for establishing the stereogenic centers at C8 and C9, a biomim...

Total syntheses of (-)-transtaganolide A, (+)-transtaganolide B, (+)-transtaganolide C, and (-)-transtaganolide D and biosynthetic implications.

Plants belonging to the genus Thapsia have been acknowledged since antiquity for their remarkable medicinal properties. Until very recently, this has been attributed to their primary chemical component thapsigargin (Figure 1a), a widely utilized and structurally complex sesquiterpenoid metabolite known for its potent SERCA inhibition. Within the past decade, an additional group of structurally ...

Thermodynamic and Economic Optimization of a Refrigeration Cycle for Separation Units in the Petrochemical Plants Using Pinch Technology and Exergy Syntheses Analysis

Exergy and thermoeconomic analyses are herein employed to evaluate the proposed refrigeration cycle of Tabriz olefin plant. The exergetic and exergoeconomic variables of all equipment and streams are calculated. Thermoeconomic model is developed according to the total revenue requirement (TRR) method. The results indicate that the rational efficiencies of the Heat Exchanger E-104 and compressor...